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Title: Identification of novel derivative of helvolic acid from Metarhizium anisopliae grown in medium with insect component
Authors: Si Young Lee
Hiroshi Kinoshita
Fumio Ihara
Yasuhiro Igarashi
Takuya Nihira
Osaka University
Institute of Fruit Tree and Tea Science, NARO
Toyama Prefectural University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering
Issue Date: 1-May-2008
Citation: Journal of Bioscience and Bioengineering. Vol.105, No.5 (2008), 476-480
Abstract: Entomopathogenic fungi are unique owing to their versatile ability to produce many bioactive compounds and from the dependence of their morphological differentiation on the presence of insect-derived materials. An entomopathogenic fungus, Metarhizium anisopliae HF293, was found to show insect-material-dependent production of antibacterial compounds, which were purified to homogeneity from 10-d culture broth when the production reached maximum. Two compounds were isolated: the major compound was determined to be helvolic acid and the minor one was a novel derivative of helvolic acid (1,2-dihydrohelvolic acid). Discovery of a novel bioactive compound indicated that insect-derived material would be a useful factor for enhancing the diversity of compounds produced by entomopathogenic fungi. © 2008 The Society for Biotechnology, Japan.
ISSN: 13891723
Appears in Collections:Scopus 2006-2010

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