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dc.contributor.authorManeekarn Chinworrungseeen_US
dc.contributor.authorSuthep Wiyakruttaen_US
dc.contributor.authorNongluksna Sriubolmasen_US
dc.contributor.authorPhitaya Chuailuaen_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.date.accessioned2018-07-12T02:18:58Z-
dc.date.available2018-07-12T02:18:58Z-
dc.date.issued2008-05-01en_US
dc.identifier.citationArchives of Pharmacal Research. Vol.31, No.5 (2008), 611-616en_US
dc.identifier.issn19763786en_US
dc.identifier.issn02536269en_US
dc.identifier.other2-s2.0-43749109407en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=43749109407&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/18934-
dc.description.abstractBioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=43749109407&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocrealesen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1007/s12272-001-1201-xen_US
Appears in Collections:Scopus 2006-2010

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