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Title: Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales
Authors: Maneekarn Chinworrungsee
Suthep Wiyakrutta
Nongluksna Sriubolmas
Phitaya Chuailua
Apichart Suksamrarn
Srinakharinwirot University
Mahidol University
Chulalongkorn University
Ramkhamhaeng University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-May-2008
Citation: Archives of Pharmacal Research. Vol.31, No.5 (2008), 611-616
Abstract: Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.
ISSN: 19763786
Appears in Collections:Scopus 2006-2010

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