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Title: Activation of 5-HT1A receptors attenuates tachycardia induced by restraint stress in rats
Authors: Sukonthar Ngampramuan
Mathias Baumert
Mirza Irfan Beig
Naiphinich Kotchabhakdi
Eugene Nalivaiko
The Institute of Science and Technology for Research and Development, Mahidol University
University of Adelaide
Flinders University
Flinders Medical Centre
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2008
Citation: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. Vol.294, No.1 (2008)
Abstract: To better understand the central mechanisms that mediate increases in heart rate (HR) during psychological stress, we examined the effects of systemic and intramedullary (raphe region) administration of the serotonin-1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) on cardiac changes elicited by restraint in hooded Wistar rats with preimplanted ECG telemetric transmitters. 8-OH-DPAT reduced basal HR from 356 ± 12 to 284 ± 12 beats/min, predominantly via a nonadrenergic, noncholinergic mechanism. Restraint stress caused tachycardia (an initial transient increase from 318 ± 3 to 492 ± 21 beats/min with a sustained component of 379 ± 12 beats/min). β-Adrenoreceptor blockade with atenolol suppressed the sustained component, whereas muscarinic blockade with methylscopolamine (50 μg/kg) abolished the initial transient increase, indicating that sympathetic activation and vagal withdrawal were responsible for the tachycardia. Systemic administration of 8-OH-DPAT (10, 30, and 100 μg/kg) attenuated stress-induced tachycardia in a dose-dependent manner, and this effect was suppressed by the 5-HT1Aantagonist WAY-100635 (100 μg/kg). Given alone, the antagonist had no effect. Systemically injected 8-OH-DPAT (100 μg/kg) attenuated the sympathetically mediated sustained component (from +85 ± 19 to +32 ± 9 beats/min) and the vagally mediated transient (from +62 ± 5 to +25 ± 3 beats/min). Activation of 5-HT1Areceptors in the medullary raphe by microinjection of 8-OH-DPAT mimicked the antitachycardic effect of the systemically administered drug but did not affect basal HR. We conclude that tachycardia induced by restraint stress is due to a sustained increase in cardiac sympathetic activity associated with a transient vagal withdrawal. Activation of central 5-HT1Areceptors attenuates this tachycardia by suppressing autonomic effects. At least some of the relevant receptors are located in the medullary rapheparapyramidal area. Copyright © 2008 the American Physiological Society.
ISSN: 15221490
Appears in Collections:Scopus 2006-2010

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