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Title: Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
Authors: Vilailak Prachyawarakorn
Chulabhorn Mahidol
Sanya Sureram
Suwannee Sangpetsiripan
Suthep Wiyakrutta
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulabhorn Graduate Institute
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2008
Citation: Planta Medica. Vol.74, No.1 (2008), 69-72
Abstract: Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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