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|Title:||Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales|
Chulabhorn Research Institute
Chulabhorn Graduate Institute
The Institute of Science and Technology for Research and Development, Mahidol University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Planta Medica. Vol.74, No.1 (2008), 69-72|
|Abstract:||Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.|
|Appears in Collections:||Scopus 2006-2010|
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