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dc.contributor.authorChintana Tocharoentanapholen_US
dc.contributor.authorSomying Promsoen_US
dc.contributor.authorDianna Zelenikaen_US
dc.contributor.authorTassanee Lowhnooen_US
dc.contributor.authorSissades Tongsimaen_US
dc.contributor.authorThanyachai Suraen_US
dc.contributor.authorWasun Chantratitaen_US
dc.contributor.authorFumihiko Matsudaen_US
dc.contributor.authorSean Mooneyen_US
dc.contributor.authorAnavaj Sakuntabhaien_US
dc.contributor.otherCentre National de Genotypageen_US
dc.contributor.otherChulabhorn Cancer Centeren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherIndiana University School of Medicine Indianapolisen_US
dc.identifier.citationJournal of Human Genetics. Vol.53, No.1 (2008), 74-86en_US
dc.description.abstractIn the candidate gene approach, information about the distribution of single nucleotide polymorphisms (SNPs) is a crucial requirement for choosing efficient markers necessary for a case-control association study. To obtain such information, we discovered SNPs in 13 genes related to atherosclerosis by resequencing exon-flanking regions of 32 healthy Thai individuals. In total, 194 polymorphisms were identified, 184 of them SNPs, four insertions, and the rest deletions. Fifty-nine of the SNPs were characterized as novel polymorphisms, and these accounted for 30% of the identified SNPs. Comparing allele frequency distributions of the Thai population with other Asian populations shows similar patterns. In contrast, a low correlation pattern (r = 0.521) was found when comparing with either Caucasian or African populations. However, some rare alleles (rs11574541 and rs10874913) are found in the Thai population but not in other Asian populations. Most of the novel SNPs found were located outside the haplotype blocks generated by known SNPs in the Thai population. Only 5.77% of the novel SNPs lies in these defined haplotype blocks. The selection of haplotype-tagging SNPs shows that 8 of 13 genes benefited from the ethnic-specific genotype information. That is, when at least one novel SNP was present, the tagging SNPs chosen were altered. Functional prediction of 16 nonsynonymous SNPs (nsSNPs) by three different algorithm tools demonstrated that five nsSNPs possibly alter their corresponding protein functions. These results provide necessary information for conducting further genetic association studies involving the Thai population and demonstrate that resequencing of candidate genes provides more complete information for full genetic studies. © 2007 The Japan Society of Human Genetics and Springer.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleEvaluation of resequencing on number of tag SNPs of 13 atherosclerosis- related genes in Thai populationen_US
Appears in Collections:Scopus 2006-2010

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