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Title: Association between ADAM33 polymorphisms and asthma in a Thai population
Authors: Torpong Thongngarm
Aree Jameekornrak
Chanin Limwongse
Atik Sangasapaviliya
Orathai Jirapongsananuruk
Anunchai Assawamakins
Nachol Chaiyaratana
Voravich Luangwedchakarn
Wanna Thongnoppakhun
Mahidol University
Pramongkutklao Hospital
King Mongkut's University of Technology North Bangkok
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2008
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.26, No.4 (2008), 205-211
Abstract: ADAM33 (A Disintegrin And Metalloprotease 33) is an asthma susceptibility gene found across several human populations. However, no information on ADAM33 exists for Thai population. The objective of this study was to determine the association, if any, between ADAM33 polymorphisms and asthma in Thai subjects. Genotyping revealed 8 single nucleotide polymorphisms (SNPs) within the 3′ region of the ADAM33 gene among 200 asthmatics and 100 control subjects. Asthmatic subjects were further sub-categorized into high and low severity groups. Multiple genetic model statistic tests for single-marker and haplotype association were carried out. Differences in allele frequencies at the SNPs rs528557/S2, rs598418 and rs44707/ST+4 in asthmatics were statistically significant compared to controls. The SNP rs528557/S2 could also be linked to the low severity group and the SNPs rs598418 and rs44707/ST+4 with the high severity group. Two-SNP haplotype analysis at the SNPs rs528557/S2 and rs598418 revealed a significant association with asthma. This study in a Thai population confirmed a positive association between ADAM33 polymorphisms and asthma susceptibility.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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