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Title: Analyses of vaccination protocols for Leptospira interrogans serovar Autumnalis in hamsters
Authors: Amporn Srikram
Surasakdi Wongratanacheewin
Anucha Puapairoj
Vanaporn Wuthiekanun
Rasana W. Sermswan
Khon Kaen University
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2008
Citation: American Journal of Tropical Medicine and Hygiene. Vol.79, No.5 (2008), 779-786
Abstract: Leptospirosis, caused by Leptospira spp., is a zoonotic disease found worldwide. Killed whole cell leptospiral vaccines have been used as effective vaccines to elicit specific antibodies for protection. However, the involvement of cytokine responses after vaccination is not well characterized. Hamsters were immunized with killed L. interrogans serovar Autumnalis before challenge to study cytokine mRNA expression levels (interferon [IFN]-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-10, and IL-4). Vaccinated groups showed 92-100% survival rates, whereas control hamsters died within 6-10 days. However, live organisms were detected in vaccinated groups, and mild to moderate pathology was observed early in infection. IFN-γ and TNF-α mRNA expression levels correlated with the severity of infection and lung pathology, whereas IL-4 and IL-10 expression levels were significantly higher in vaccinated groups. In summary, commonly used vaccines changed the cytokine profiles and protected hamsters from death but failed to stimulate sterile immunity and were unable to prevent the occurrence of pathology. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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