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Title: Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation
Authors: Thanat Chookajorn
Patrath Ponsuwanna
Liwang Cui
Mahidol University
Pennsylvania State University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2008
Citation: Trends in Parasitology. Vol.24, No.10 (2008), 455-461
Abstract: As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation. © 2008 Elsevier Ltd. All rights reserved.
ISSN: 14714922
Appears in Collections:Scopus 2006-2010

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