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Title: The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
Authors: Sue J. Lee
Kasia Stepniewska
Nicholas Anstey
Elizabeth Ashley
Karen Barnes
Tran Quang Binh
Umberto D'Alessandro
Nicholas P.J. Day
Peter J. De Vries
Grant Dorsey
Jean Paul Guthmann
Mayfong Mayxay
Paul Newton
Francois Nosten
Piero Olliaro
Lyda Osario
Loretxu Pinoges
Ric Price
Mark Rowland
Frank Smithuis
Robert Taylor
Nicholas J. White
Mahidol University
Royal Darwin Hospital
Shoklo Malaria Research Unit
University of Cape Town
Choray Hospital
Prins Leopold Instituut voor Tropische Geneeskunde
Centre for Clinical Vaccinology and Tropical Medicine
Academic Medical Centre, University of Amsterdam
University of California, San Francisco
Institut de Recherche en Sciences de la Santé
Uganda Malaria Surveillance Program
National University of Laos
University of Oxford
Organisation Mondiale de la Sante
Centro Internatcional de Entrenamiento e Investigaciones Medicas
London School of Hygiene & Tropical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 22-Aug-2008
Citation: Malaria Journal. Vol.7, (2008)
Abstract: Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. Results. A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). Conclusion. Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. © 2008 Lee et al; licensee BioMed Central Ltd.
ISSN: 14752875
Appears in Collections:Scopus 2006-2010

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