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Title: Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report
Authors: Marcus J. Rijken
Rose McGready
Machteld E. Boel
Marion Barends
Stephane Proux
Mupawjay Pimanpanarak
Pratap Singhasivanon
François Nosten
Shoklo Malaria Research Unit
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Apr-2008
Citation: American Journal of Tropical Medicine and Hygiene. Vol.78, No.4 (2008), 543-545
Abstract: Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4). Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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