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|Title:||Genetic typing of the 56-kDa type-specific antigen gene of contemporary Orientia tsutsugamushi isolates causing human scrub typhus at two sites in north-eastern and western Thailand|
|Authors:||Stuart D. Blacksell|
Daniel H. Paris
Sharon J. Peacock
N. P J Day
John Radcliffe Hospital
Shoklo Malaria Research Unit
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||FEMS Immunology and Medical Microbiology. Vol.52, No.3 (2008), 335-342|
|Abstract:||Orientia tsutsugamushi is the causative agent of scrub typhus, a major cause of febrile illness in the rural areas of Southeast Asia. Twenty-three strains of O. tsutsugamushi were isolated from patients with scrub typhus in north-east (Udorn Thani province) and western Thailand (Tak province) between 2003 and 2005. The isolates were characterized by sequencing the entire ORF of the 56-kDa-type-specific antigen gene, followed by phylogenetic analysis. The majority (15/23) of isolates clustered with the Karp-type strain, six with a Gilliam-type strain and one each with the TA716- and TA763-type strains. Overall, there was considerable diversity in sequence, comparable to that seen in strains from across the rest of the scrub typhus-endemic world. There was no significant difference in the distributions of strains between the two provinces (P=0.08, Fisher's exact) nor a temporal change in distribution with year of isolation (P=0.80, Fisher's exact). Within this diversity there were also examples of isolates with identical 56-kDa genotypes that were cultured from patients from the same geographical areas. © 2008 University of Oxford.|
|Appears in Collections:||Scopus 2006-2010|
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