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Title: Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Authors: Nicholas J. White
Kasia Stepniewska
Karen Barnes
Ric N. Price
Julie Simpson
Mahidol University
Churchill Hospital
University of Cape Town
Menzies School of Health Research
University of Melbourne
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Apr-2008
Citation: Trends in Parasitology. Vol.24, No.4 (2008), 159-163
Abstract: The blood concentration profiles of most antimalarial drugs vary considerably between patients. The interpretation of antimalarial drug trials evaluating efficacy and effectiveness would be improved considerably if the exposure of the infecting parasite population to the antimalarial drug treatment could be measured. Artemisinin combination treatments are now recommended as first-line drugs for the treatment of falciparum malaria. Measurement of the blood, serum or plasma concentration of the slowly eliminated partner antimalarial drug on day 7 of follow-up is simpler and might be a better determinant of therapeutic response than the area under the concentration-time curve. Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials. © 2008 Elsevier Ltd. All rights reserved.
ISSN: 14714922
Appears in Collections:Scopus 2006-2010

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