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Title: The VIZIER project: Preparedness against pathogenic RNA viruses
Authors: B. Coutard
A. E. Gorbalenya
E. J. Snijder
A. M. Leontovich
A. Poupon
X. De Lamballerie
R. Charrel
E. A. Gould
S. Gunther
H. Norder
B. Klempa
H. Bourhy
J. Rohayem
E. L'hermite
P. Nordlund
D. I. Stuart
R. J. Owens
J. M. Grimes
P. A. Tucker
M. Bolognesi
A. Mattevi
M. Coll
T. A. Jones
J. Åqvist
T. Unge
R. Hilgenfeld
G. Bricogne
J. Neyts
P. La Colla
G. Puerstinger
J. P. Gonzalez
E. Leroy
C. Cambillau
J. L. Romette
B. Canard
Universite de Provence Aix-Marseille 1
CNRS Centre National de la Recherche Scientifique
Center of Infectious Diseases
Faculte de Medecine de Marseille Universite de la Mediterranee
Centre for Ecology & Hydrology
Swedish Institute for Infectious Disease Control
Institute of Virology Slovak Academy of Sciences
Institut Pasteur, Paris
Bernhard Nocht Institut fur Tropenmedizin Hamburg
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
University of Oxford
Deutsche Elektronen-Synchrotron
Universita degli Studi di Milano
Universita degli Studi di Pavia
CSIC - Instituto de Biologia Molecular de Barcelona (IBMB)
Global Phasing Ltd
Uppsala Biomedicinska Centrum
Universität zu Lübeck
KU Leuven
Universita degli Studi di Cagliari
Mahidol University
University of Innsbruck
Lomonosov Moscow State University
Stockholms universitet
Keywords: Immunology and Microbiology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Apr-2008
Citation: Antiviral Research. Vol.78, No.1 (2008), 37-46
Abstract: Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) ( project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules. © 2007 Elsevier B.V. All rights reserved.
ISSN: 01663542
Appears in Collections:Scopus 2006-2010

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