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Title: Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: A cross-sectional study
Authors: Ravi Retnakaran
Byung Soo Youn
Ying Liu
Anthony J G Hanley
Nam Seok Lee
Ji Woo Park
Eun Sun Song
Vivian Vu
Wi Kim
Rungsunn Tungtrongchitr
Peter J. Havel
Michael M. Swarbrick
Collin Shaw
Gary Sweeney
York University
Mount Sinai Hospital of University of Toronto
University of Toronto
Korea University
Mahidol University
University of California, Davis
ALPCO Diagnostics
Keywords: Medicine
Issue Date: 1-Dec-2008
Citation: Clinical Endocrinology. Vol.69, No.6 (2008), 885-893
Abstract: Objective: Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters. Design, patients and measurements: We established the specificity and effectiveness of the new ELISA and evaluated the associations of full-length visfatin with clinical, anthropometric and metabolic parameters in a cross-sectional study of 129 Thai subjects, consisting of 50 outpatients with type 2 diabetes and 79 healthy volunteers. Results: The new ELISA accurately recovered full-length recombinant visfatin and detected visfatin secreted by primary human and rat adipocytes. We found serum full-length visfatin was significantly higher in subjects with diabetes compared to their nondiabetic peers (median 2.75 vs. 2.22 ng/ml, P = 0.0142). After adjustment for age, gender and traditional metabolic risk factors, adjusted mean visfatin remained significantly higher in the diabetes group (3.80 vs. 2.10 ng/ml, P = 0.0021). On Spearman univariate correlation analysis, visfatin was significantly associated with resistin (r = 0.30, P = 0.0011), but not with any other anthropometric or metabolic variables, including adiponectin multimers. On multiple linear regression analysis, the only covariates independently associated with visfatin were diabetes (t = 3.11, P = 0.0024) and log resistin (t = 2.68, P = 0.0086). Conclusions: Circulating visfatin is independently associated with diabetes and resistin concentration, but is not related to adiponectin multimers or other metabolic covariates. These data are suggestive of a potential role of visfatin in subclinical inflammatory states. © 2008 The Authors.
ISSN: 13652265
Appears in Collections:Scopus 2006-2010

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