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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/19496
Title: Association between fertility and molecular sub-type of global isolates of Cryptococcus gattii molecular type VGII
Authors: Popchai Ngamskulrungroj
Tania Sorrell
Ariya Chindamporn
Angkana Chaiprasert
Natthiwan Poonwan
Wieland Meyer
Westmead Hospital
The University of Sydney
Mahidol University
Chulalongkorn University
National Institutes of Health, Bethesda
Keywords: Medicine
Issue Date: 1-Nov-2008
Citation: Medical Mycology. Vol.46, No.7 (2008), 665-673
Abstract: The basidiomycetous yeast Cryptococcus gattii, is a primary pathogen which causes disease in apparently healthy humans and a wide range of animals. Recently, an outbreak of cryptococcosis caused by a previously uncommon genotype of C. gattii, VGII, emerged on Vancouver Island, British Columbia, Canada. Two pathogenic sub-types of VGII (designated VGIIa and VGIIb) were identified among these isolates. All of the isolates proved to be mating type α and had exceptionally high sporulation capacity. The common subtype, VGIIa, was more virulent than VGIIb in mice, suggesting a linkage between subtype and fertility/ virulence. To test this hypothesis, we compared the fertility of 91 isolates from the Vancouver Island outbreak with that of 72 VGII isolates selected globally. Of all isolates, 69.94% were found to be fertile and exhibited clamp connections and basidiospores. The Vancouver isolates showed a high fertility rate of 84.2% as compared to only 29% of the 21 Australian isolates investigated. Mating type α strains were more fertile (72.79%) than mating type a (43.75%) (p < 0.022). Amongst the two subtypes of VGII a much higher proportion of VGIIa (91.7%) than VGIIb (33.3%) was fertile (p < 0.001). These results suggest that there is a clear correlation between the VGII subtypes of C. gattii and their mating/fertility. Further in vitro and in vivo investigations of more strains and congenic pairs are warranted.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55149103987&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/19496
ISSN: 14602709
13693786
Appears in Collections:Scopus 2006-2010

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