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dc.contributor.authorPopchai Ngamskulrungrojen_US
dc.contributor.authorTania Sorrellen_US
dc.contributor.authorAriya Chindampornen_US
dc.contributor.authorAngkana Chaipraserten_US
dc.contributor.authorNatthiwan Poonwanen_US
dc.contributor.authorWieland Meyeren_US
dc.contributor.otherWestmead Hospitalen_US
dc.contributor.otherThe University of Sydneyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherNational Institutes of Health, Bethesdaen_US
dc.identifier.citationMedical Mycology. Vol.46, No.7 (2008), 665-673en_US
dc.description.abstractThe basidiomycetous yeast Cryptococcus gattii, is a primary pathogen which causes disease in apparently healthy humans and a wide range of animals. Recently, an outbreak of cryptococcosis caused by a previously uncommon genotype of C. gattii, VGII, emerged on Vancouver Island, British Columbia, Canada. Two pathogenic sub-types of VGII (designated VGIIa and VGIIb) were identified among these isolates. All of the isolates proved to be mating type α and had exceptionally high sporulation capacity. The common subtype, VGIIa, was more virulent than VGIIb in mice, suggesting a linkage between subtype and fertility/ virulence. To test this hypothesis, we compared the fertility of 91 isolates from the Vancouver Island outbreak with that of 72 VGII isolates selected globally. Of all isolates, 69.94% were found to be fertile and exhibited clamp connections and basidiospores. The Vancouver isolates showed a high fertility rate of 84.2% as compared to only 29% of the 21 Australian isolates investigated. Mating type α strains were more fertile (72.79%) than mating type a (43.75%) (p < 0.022). Amongst the two subtypes of VGII a much higher proportion of VGIIa (91.7%) than VGIIb (33.3%) was fertile (p < 0.001). These results suggest that there is a clear correlation between the VGII subtypes of C. gattii and their mating/fertility. Further in vitro and in vivo investigations of more strains and congenic pairs are warranted.en_US
dc.rightsMahidol Universityen_US
dc.titleAssociation between fertility and molecular sub-type of global isolates of Cryptococcus gattii molecular type VGIIen_US
Appears in Collections:Scopus 2006-2010

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