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Title: Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m<sup>2</sup>/day
Authors: Vutisiri Veerasarn
Wiroon Boonnuch
Vitoon Chinswangwatanakul
Darin Lohsiriwat
Pranee Mahamadsolaeh
Mahidol University
Keywords: Medicine
Issue Date: 1-Oct-2008
Citation: Journal of the Medical Association of Thailand. Vol.91, No.10 (2008), 1583-1588
Abstract: Objective: Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine. Material and Method: Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks. Results: After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported. Conclusion: Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated. The potential dose limiting toxicity effect was the diarrhea.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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