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Title: Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro
Authors: Jens Raffelsberger
Gunther Wernsdorfer
Jeeraphat Sirichaisinthop
Herwig Kollaritsch
Kanungnit Congpuong
Walther H. Wernsdorfer
Medizinische Universitat Wien
Mahidol University
Thailand Ministry of Public Health
Universitetssjukhuset i Linkoping
Keywords: Medicine
Issue Date: 1-Oct-2008
Citation: Wiener Klinische Wochenschrift. Vol.120, No.SUPPL. 4 (2008), 90-94
Abstract: The sensitivity of Plasmodium falciparum against artemisinin, monodebutyl-benflumetol (DBB) and a 1:3 m/m combination of both compounds was assessed in 51 fresh parasite isolates. Although a comparison between fully inhibitory concentrations (GMCOC) of artemisinin alone (63.33 nM), DBB alone (50.15 nM) and the combination (23.92 nM) indicated significant synergism between artemisinin and DBB, this was less evident when comparing the log-probit regressions. Moreover, the geometric mean values of the fractional inhibitory concentrations (SFIC) showed a rising tendency with increasing EC level. In a study comprising 24 fresh isolates of P. falciparum, the interaction between DBB and proguanil was explored with a 3:1 m/m combination of both compounds. Proguanil alone showed weak blood schizontocidal activity. The log-probit regressions indicated higher activity of the combination as compared to DBB alone. The SFIC values indicated moderate synergism between DBB and proguanil that could be an advantage in an eventual therapeutic and prophylactic use of DBB. © 2008 Springer-Verlag.
ISSN: 00435325
Appears in Collections:Scopus 2006-2010

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