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dc.contributor.authorJens Raffelsbergeren_US
dc.contributor.authorGunther Wernsdorferen_US
dc.contributor.authorJeeraphat Sirichaisinthopen_US
dc.contributor.authorHerwig Kollaritschen_US
dc.contributor.authorKanungnit Congpuongen_US
dc.contributor.authorWalther H. Wernsdorferen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherUniversitetssjukhuset i Linkopingen_US
dc.identifier.citationWiener Klinische Wochenschrift. Vol.120, No.SUPPL. 4 (2008), 90-94en_US
dc.description.abstractThe sensitivity of Plasmodium falciparum against artemisinin, monodebutyl-benflumetol (DBB) and a 1:3 m/m combination of both compounds was assessed in 51 fresh parasite isolates. Although a comparison between fully inhibitory concentrations (GMCOC) of artemisinin alone (63.33 nM), DBB alone (50.15 nM) and the combination (23.92 nM) indicated significant synergism between artemisinin and DBB, this was less evident when comparing the log-probit regressions. Moreover, the geometric mean values of the fractional inhibitory concentrations (SFIC) showed a rising tendency with increasing EC level. In a study comprising 24 fresh isolates of P. falciparum, the interaction between DBB and proguanil was explored with a 3:1 m/m combination of both compounds. Proguanil alone showed weak blood schizontocidal activity. The log-probit regressions indicated higher activity of the combination as compared to DBB alone. The SFIC values indicated moderate synergism between DBB and proguanil that could be an advantage in an eventual therapeutic and prophylactic use of DBB. © 2008 Springer-Verlag.en_US
dc.rightsMahidol Universityen_US
dc.titlePharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitroen_US
Appears in Collections:Scopus 2006-2010

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