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Title: Synergism between quinine and retinol in fresh isolates of Plasmodium falciparum
Authors: Ariane Knauer
Kanungnit Congpuong
Gunther Wernsdorfer
Franz F. Reinthaler
Jeeraphat Sirichaisinthop
Walther H. Wernsdorfer
Medizinische Universitat Graz
Thailand Ministry of Public Health
Mahidol University
Medizinische Universitat Wien
Keywords: Medicine
Issue Date: 1-Oct-2008
Citation: Wiener Klinische Wochenschrift. Vol.120, No.SUPPL. 4 (2008), 69-73
Abstract: Following earlier reports of synergism between retinol and various antimalarial compounds, the pharmacodynamic interaction between retinol and quinine was investigated in 38 fresh isolates of Plasmodium falciparum. The study was carried out in western Thailand, an area with quinine-resistant P. falciparum. The combination of quinine with retinol in concentrations corresponding to the 50th, 65thand 80thpercentile of the physiological values in healthy subjects, significantly reduced the EC50, EC90, EC99and GMCOC for quinine. The FIC values at EC90and EC99indicate increasing synergism with rising EC and retinol concentration. The mean SFIC value dropped to a level as low as 0.2420, indicating strong synergism. © 2008 Springer-Verlag.
ISSN: 00435325
Appears in Collections:Scopus 2006-2010

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