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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/19532
Title: Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
Authors: Sue Jean Lee
Rose McGready
Christine Fernandez
Kasia Stepniewska
Moo Koo Paw
Samuel Jacher Viladpai-Nguen
Kyaw Lay Thwai
Leopoldo Villegas
Pratap Singhasivanon
Brian M. Greenwood
Nicholas J. White
François Nosten
Shoklo Malaria Research Unit
Mahidol University
Hopital Pitie Salpetriere
Universite Paris-Sud XI
Instituto de Altos Estudios en Salud Pública
London School of Hygiene & Tropical Medicine
Churchill Hospital
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2008
Citation: European Journal of Clinical Pharmacology. Vol.64, No.10 (2008), 987-992
Abstract: Purpose: We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria. Methods: Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study. Results: Although increasing gestational age was associated with reduced chloroquine AUC0→∞, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0→∞values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy. Conclusions: Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria. © 2008 The Author(s).
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=53249137892&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/19532
ISSN: 00316970
Appears in Collections:Scopus 2006-2010

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