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dc.contributor.authorWattana Leowattanaen_US
dc.contributor.authorSrivicha Krudsooden_US
dc.contributor.authorNoppadon Tangpukdeeen_US
dc.contributor.authorGary Brittenhamen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherColumbia University Medical Centeren_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.4 (2008), 581-588en_US
dc.description.abstractTo elucidate the relationship between falciparum malaria-associated anemia and serum erythropoietin (Epo) levels and reticulocyte response during acute malaria infection, 87 adults aged 18-65 years presenting with acute, uncomplicated malaria were examined on enrollment and for 28 days of follow-up. The 87 patients were divided into 2 groups: those with anemia (n = 45) and those without (n = 42). Serum samples were taken on admission (Day 0), then on Days 7, 21, and 28, to measure the reticulocyte count, absolute reticulocyte count, reticulocyte hemoglobin content, and erythropoietin level (Epo). The absolute reticulocyte counts for the anemic patients were significantly higher than for those without anemia on Days 0, 7, 21, and 28. The serum Epo levels for the anemic patients were significantly higher than the non-anemic group only on Day 0 (44.39 ± 4.06 vs 25.91 ± 4.86 mlU/ml, p < 0.001). Inadequate Epo production was found in 31.03% (27/87) of patients on Day 0, 37.93% (33/87) on Day 7, 43.67% (38/87) on Day 21, and 39.08% (34/87) on Day 28. These results indicate defective Epo production and reticulocyte response in adult patients suffering from acute P. falciparum malaria, which differs from pediatric patients. Our findings may provide the basis for further study into the choice of therapeutic strategies to treat acute P. falciparum malaria-associated anemia with recombinant human Epo to correct refractory anemia due to malaria.en_US
dc.rightsMahidol Universityen_US
dc.titleDefective erythropoietin production and reticulocyte response in acute plasmodium falciparum malaria-associated anemiaen_US
Appears in Collections:Scopus 2006-2010

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