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dc.contributor.authorM. B. Zimmermannen_US
dc.contributor.authorC. Zederen_US
dc.contributor.authorS. Muthayyaen_US
dc.contributor.authorP. Winichagoonen_US
dc.contributor.authorN. Chaoukien_US
dc.contributor.authorI. Aeberlien_US
dc.contributor.authorR. F. Hurrellen_US
dc.contributor.otherETH Zurichen_US
dc.contributor.otherWageningen University and Research Centreen_US
dc.contributor.otherSt. John's National Academy Of Health Sciences Indiaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMinistry of Health, Moroccoen_US
dc.date.accessioned2018-07-12T02:41:36Z-
dc.date.available2018-07-12T02:41:36Z-
dc.date.issued2008-07-01en_US
dc.identifier.citationInternational Journal of Obesity. Vol.32, No.7 (2008), 1098-1104en_US
dc.identifier.issn14765497en_US
dc.identifier.issn03070565en_US
dc.identifier.other2-s2.0-47249153165en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47249153165&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/19625-
dc.description.abstractBackground: Overweight is increasing in transition countries, while iron deficiency remains common. In industrialized countries, greater adiposity increases risk of iron deficiency. Higher hepcidin levels in obesity may reduce dietary iron absorption. Therefore, we investigated the association between body mass index (BMI) and iron absorption, iron status and the response to iron fortification in populations from three transition countries (Thailand, Morocco and India). Methods: In Thai women (n=92), we examined the relationship between BMI and iron absorption from a reference meal containing ∼4 mg of isotopically labeled fortification iron. We analyzed data from baseline (n=1688) and intervention (n=727) studies in children in Morocco and India to look for associations between BMI Z-scores and baseline hemoglobin, serum ferritin and transferrin receptor, whole blood zinc protoporphyrin and body iron stores, and changes in these measures after provision of iron. Results: In the Thai women, 20% were iron deficient and 22% were overweight. Independent of iron status, a higher BMI Z-score was associated with decreased iron absorption (P=0.030). In the Indian and Moroccan children, 42% were iron deficient and 6.3% were overweight. A higher BMI Z-score predicted poorer iron status at baseline (P<0.001) and less improvement in iron status during the interventions (P<0.001). Conclusions: Adiposity in young women predicts lower iron absorption, and pediatric adiposity predicts iron deficiency and a reduced response to iron fortification. These data suggest the current surge in overweight in transition countries may impair efforts to control iron deficiency in these target groups. Interactions of the 'double burden' of malnutrition during the nutrition transition may have adverse consequences. © 2008 Macmillan Publishers Limited All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47249153165&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectNursingen_US
dc.titleAdiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortificationen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/ijo.2008.43en_US
Appears in Collections:Scopus 2006-2010

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