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Title: Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection
Authors: Wendy Bhanich Supapol
Robert S. Remis
Janet Raboud
Margaret Millson
Jordan Tappero
Rupert Kaul
Prasad Kulkarni
Michelle S. McConnell
Philip A. Mock
Mary Culnane
Janet McNicholl
Anuvat Roongpisuthipong
Tawee Chotpitayasunondh
Nathan Shaffer
Salvatore Butera
University of Toronto Faculty of Medicine
University Health Network University of Toronto
Thailand Ministry of Public Health
Mahidol University
Queen Sirikit National Institute of Child Health
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Centers for Disease Control and Prevention
University of Toronto
Keywords: Medicine
Issue Date: 15-May-2008
Citation: Journal of Infectious Diseases. Vol.197, No.10 (2008), 1369-1377
Abstract: Background. Prolonged coinfection with GB virus C (GBV-C) has been associated with improved survival in human immunodeficiency virus (HIV)-infected adults. We investigated whether maternal or infant GBV-C infection was associated with mother-to-child transmission (MTCT) of HIV-1 infection. Methods. The study population included 1364 HIV-infected pregnant women enrolled in 3 studies of MTCT of HIV in Bangkok, Thailand (the studies were conducted from 1992-1994, 1996-1997, and 1999-2004, respectively). We tested plasma collected from pregnant women at delivery for GBV-C RNA, GBV-C antibody, and GBV-C viral genotype. If GBV-CRNAwas detected in the maternal samples, the 4- or 6-month infant sample was tested for GBV-C RNA. The rates of MTCT of HIV among GBV-C-infected women and infants were compared with the rates among women and infants without GBV-C infection. Results. The prevalence of GBV-C RNA in maternal samples was 19%. Of 245 women who were GBV-C RNA positive, 101 (41%) transmitted GBV-C to their infants. Of 101 infants who were GBV-C RNA positive, 2 (2%) were infected with HIV, compared with 162 (13%) of 1232 infants who were GBV-C RNA negative (odds ratio [OR] adjusted for study, 0.13 [95% confidence interval {CI}, 0.03-0.54]). This association remained after adjustment for maternal HIV viral load, receipt of antiretroviral prophylaxis, CD4+count, and other covariates. MTCT of HIV was not associated with the presence of GBV-C RNA (adjusted OR [aOR], 0.94 [95% CI, 0.62-1.42]) or GBV-C antibody (aOR, 0.90 [95% CI, 0.54-1.50]) in maternal samples. Conclusions. Reduced MTCT of HIV was significantly associated with infant acquisition of GBV-C but not with maternal GBV-C infection. The mechanism for this association remains unknown. © 2008 by the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

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