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|Title:||Cloning and heterologous expression of Cryptococcus neoformans CnSRB1 cDNA in Saccharomyces cerevisiae|
Lubomira I. Stateva
Thailand National Center for Genetic Engineering and Biotechnology
University of Manchester
|Citation:||Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.3 (2008), 484-491|
|Abstract:||In this study, we report the results of cloning, sequencing and functional analysis by complementation test of the putative Cryptococcus neoformans homolog CnSRB1. The nucleotide sequence revealed 63% identity, and the deduced amino acid sequence showed 66 and 64% identity to its respective homolog of Saccharomyces cerevisiae and Candida albicans, respectively. Functional complementation test indicated that the putative CnSRB1 gene could compensate the defect caused by a mutation in ScSRB1 in the S. cerevisiae srb1 mutant. Taken together, these results suggest that the putative CnSrb1p is a functional homolog of ScSrb1p.|
|Appears in Collections:||Scopus 2006-2010|
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