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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/19685
Title: Cloning and heterologous expression of Cryptococcus neoformans CnSRB1 cDNA in Saccharomyces cerevisiae
Authors: Saradee Warit
Lubomira I. Stateva
Prasit Palittapongarnpim
Thailand National Center for Genetic Engineering and Biotechnology
University of Manchester
Mahidol University
Keywords: Medicine
Issue Date: 1-May-2008
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.3 (2008), 484-491
Abstract: In this study, we report the results of cloning, sequencing and functional analysis by complementation test of the putative Cryptococcus neoformans homolog CnSRB1. The nucleotide sequence revealed 63% identity, and the deduced amino acid sequence showed 66 and 64% identity to its respective homolog of Saccharomyces cerevisiae and Candida albicans, respectively. Functional complementation test indicated that the putative CnSRB1 gene could compensate the defect caused by a mutation in ScSRB1 in the S. cerevisiae srb1 mutant. Taken together, these results suggest that the putative CnSrb1p is a functional homolog of ScSrb1p.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=44949174994&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/19685
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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