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Title: Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection
Authors: Cheeraratana Cheeramakara
Vasant Khachonsaksumet
Nopachai Suthisai
Wanyarat Nakosiri
Kriyaporn Songmuaeng
Channarong Saenghirun
Duangduen Phienpicharn
Apichart Nontprasert
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-2008
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.2 (2008), 195-199
Abstract: To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 μCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 ± 34,134 dpm/cm3) than the liver (288,628.9 ± 54,954 dpm/cm3) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood: kidney: liver ratio was 1: 5: 2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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