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Title: Pueraria mirifica, phytoestrogen-induced change in synaptophysin expression via estrogen receptor in rat hippocampal neuron
Authors: Rattiya Chindewa
Saitida Lapanantasin
Yupin Sanvarinda
Sukumal Chongthammakun
Mahidol University
Keywords: Medicine
Issue Date: 1-Feb-2008
Citation: Journal of the Medical Association of Thailand. Vol.91, No.2 (2008), 208-214
Abstract: Objective: To examine Pueraria mirifica (Leguminosae) containing- phytoestrogen effect on synaptic density and involvement of estrogen receptor. Material and Method: The level of synaptophysin, a presynaptic vesicle protein, was measured using Western blot analysis and immunocytochemistry in hippocampal primary cell cultures at 6 days in vitro. Results: P. mirifica and 17?-estradiol (0.1 ?M) treatment for 4 days, but not for 2 days, significantly increased synaptophysin immunoreactivity and level of synaptophysin. P. mirifica up to 60 ?g/ml resulted in a dose related increase in the level of synaptophysin immunoreactivity. The classical estrogen receptor antagonist, ICI 182 780, significantly blocked P. mirifica-induced increase in synaptophysin. Conclusion: P. mirifica-containing phytoestrogen affects synaptic density by inducing synaptophysin expression via estrogen receptor.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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