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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/19818
Title: The use of dengue nonstructural protein 1 antigen for the early diagnosis during the febrile stage in patients with dengue infection
Authors: Ampaiwan Chuansumrit
Wathanee Chaiyaratana
Viroj Pongthanapisith
Kanchana Tangnararatchakit
Sarapee Lertwongrath
Sutee Yoksan
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2008
Citation: Pediatric Infectious Disease Journal. Vol.27, No.1 (2008), 43-48
Abstract: BACKGROUND: To evaluate the use of dengue nonstructural protein 1 (NS1) antigen for the early diagnosis during the febrile stage in patients with dengue infection. METHODS: A total of 445 sera obtained from 165 patients [dengue fever (DF): 42, dengue hemorrhagic fever (DHF) grade I: 50, II: 63, III and IV: 10] and 8 other febrile illnesses 5-15 years of age, were assayed for the NS1 antigen, dengue-specific Ig M and Ig G antibodies. RESULTS: The positive rates of NS1 antigen among patients with either DF or DHF was 100% (7 of 7) on day 2, 92.3% (12 of 13) on day 3, 76.9% (40 of 52) on day 4, 56.5% (61 of 108) on day 5 of fever; and declined to 43.1% (59 of 137) on day 6 with defervescence and 29.8% (25 of 84) on day 7 (1 day after defervescence). The positive rates of patients with DF were higher than those with DHF but no statistically significant difference was found. However, patients with primary DHF infection had significantly higher positive rates than those with secondary DHF infection. The positive rates of Ig M antibodies were in reverse proportion to those of NS1 antigen. The additional Ig M antibody determination increased the positive rates to 90.4% (47 of 52) on day 4, 83.3% (90 of 108) on day 5 of fever; 95.6% (131 of 137) on day 6 with defervescence, and 88.1% (74 of 84) on day 7. CONCLUSIONS: Dengue NS1 antigen testing is suggested as a helpful tool for the early diagnosis of dengue infection after the onset of fever. The additional Ig M antibody determination increased the diagnostic rates. © 2008 Lippincott Williams & Wilkins, Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=37549069351&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/19818
ISSN: 08913668
Appears in Collections:Scopus 2006-2010

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