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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/19845
Title: Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria
Authors: Arjen M. Dondorp
C. Ince
P. Charunwatthana
J. Hanson
A. Van Kuijen
M. A. Faiz
M. R. Rahman
M. Hasan
E. Bin Yunus
A. Ghose
R. Ruangveerayut
D. Limmathurotsakul
K. Mathura
N. J. White
N. P.J. Day
Academic Medical Centre, University of Amsterdam
Mahidol University
Mae Sot General Hospital
Nuffield Department of Clinical Medicine
Dhaka Medical College
Chittagong Medical College Hospital
Keywords: Medicine
Issue Date: 1-Jan-2008
Citation: Journal of Infectious Diseases. Vol.197, No.1 (2008), 79-84
Abstract: Background. This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. Methods. The microcirculation in the rectal mucosa of adult patients with severe malaria was assessed by use of OPS imaging, at admission and then daily. Comparison groups comprised patients with uncomplicated falciparum malaria, patients with bacterial sepsis, and healthy individuals. Results. Erythrocyte velocities were measured directly in 43 adult patients with severe falciparum malaria, of whom 20 died. Microcirculatory blood flow was markedly disturbed, with heterogeneous obstruction that was proportional to severity of disease. Blocked capillaries were found in 29 patients (67%) and were associated with concurrent hyperdynamic blood flow (erythrocyte velocity, >750 mm/s) in adjacent vessels in 27 patients (93%). The proportion of blocked capillaries correlated with the base deficit in plasma and with the concentration of lactate. Abnormalities disappeared when the patients recovered. In healthy individuals and in patients with uncomplicated malaria or sepsis, no stagnant erythrocytes were detected, and, in patients with sepsis, hyperdynamic blood flow was prominent. Conclusion. Patients with severe falciparum malaria show extensive microvascular obstruction that is proportional to the severity of the disease. This finding underscores the prominent role that microvascular obstruction plays in the pathophysiology of severe malaria and illustrates the fundamental difference between the microvascular pathophysiology of malaria and that of bacterial sepsis. © 2007 by the Infectious Diseases Society of America. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39349102894&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/19845
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

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