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Title: Attenuation of eNOS expression in cadmium-induced hypertensive rats
Authors: Nattaporn Yoopan
Piyajit Watcharasit
Orapin Wongsawatkul
Pawinee Piyachaturawat
Jutamaad Satayavivad
Mahidol University
Srinakharinwirot University
Chulabhorn Research Institute
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-Jan-2008
Citation: Toxicology Letters. Vol.176, No.2 (2008), 157-161
Abstract: Cadmium (Cd) has been reported to induce hypertension in both humans and animals; however, its mechanism has not been clearly elucidated. Vascular tone is one of the factors contributing to hypertension. This study was conducted to investigate the effects of Cd exposure on vascular muscarinic receptor responses to acetylcholine (ACh) in isolated aortas. Male Sprague-Dawley rats were exposed to Cd via drinking water (5, 10 and 50 ppm) for 3 months. Cd 10 and 50 ppm exposure caused significant decreases in the sensitivity of vascular muscarinic receptors to ACh. However, Cd exposure did not alter the vascular relaxation induced by sodium nitroprusside (SNP) which is a nitric oxide donor. Consistent with the reduction of ACh-induced relaxation, treatment with Cd decreased endothelial nitric oxide synthase (eNOS) protein level in blood vessels. These results suggested that Cd suppressed ACh-induced vascular relaxation by interfering with muscarinic receptor function, and its downstream signaling pathway may be one of the contributing factors for the development of hypertension. © 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN: 03784274
Appears in Collections:Scopus 2006-2010

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