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Title: The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
Authors: Zbynek Bozdech
Sachel Mok
Guangan Hu
Mallika Imwong
Anchalee Jaidee
Bruce Russell
Hagai Ginsburg
Francois Nosten
Nicholas P J Day
Nicholas J. White
Jane M. Carlton
Peter R. Preiser
Nanyang Technological University
Mahidol University
Agency for Science, Technology and Research, Singapore
Hebrew University of Jerusalem
NYU Langone Medical Center
Keywords: Multidisciplinary
Issue Date: 21-Oct-2008
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.105, No.42 (2008), 16290-16295
Abstract: Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to P. falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches. © 2008 by The National Academy of Sciences of the USA.
ISSN: 10916490
Appears in Collections:Scopus 2006-2010

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