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http://repository.li.mahidol.ac.th/dspace/handle/123456789/19967| Title: | Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878 |
| Authors: | Pattama Pittayakhajonwut Man Theerasilp Palangpon Kongsaeree Amporn Rungrod Morakot Tanticharoen Yodhathai Thebtaranonth Thailand National Center for Genetic Engineering and Biotechnology Mahidol University |
| Keywords: | Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 1-Nov-2002 |
| Citation: | Planta Medica. Vol.68, No.11 (2002), 1017-1019 |
| Abstract: | A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=18744369890&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/19967 |
| ISSN: | 00320943 |
| Appears in Collections: | Scopus 2001-2005 |
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