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Title: Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878
Authors: Pattama Pittayakhajonwut
Man Theerasilp
Palangpon Kongsaeree
Amporn Rungrod
Morakot Tanticharoen
Yodhathai Thebtaranonth
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2002
Citation: Planta Medica. Vol.68, No.11 (2002), 1017-1019
Abstract: A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.
ISSN: 00320943
Appears in Collections:Scopus 2001-2005

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