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|Title:||Antimalarial activity of ferrocenyl chalcones|
Mei Lin Go
National University of Singapore
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302|
|Abstract:||A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved.|
|Appears in Collections:||Scopus 2001-2005|
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