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http://repository.li.mahidol.ac.th/dspace/handle/123456789/20045| Title: | Antimalarial activity of ferrocenyl chalcones |
| Authors: | Xiang Wu Prapon Wilairat Mei Lin Go National University of Singapore Mahidol University |
| Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 2-Sep-2002 |
| Citation: | Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302 |
| Abstract: | A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037009255&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/20045 |
| ISSN: | 0960894X |
| Appears in Collections: | Scopus 2001-2005 |
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