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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20045
Title: Antimalarial activity of ferrocenyl chalcones
Authors: Xiang Wu
Prapon Wilairat
Mei Lin Go
National University of Singapore
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 2-Sep-2002
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302
Abstract: A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037009255&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20045
ISSN: 0960894X
Appears in Collections:Scopus 2001-2005

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