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Title: Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii
Authors: Namphung Vongvanich
Prasat Kittakoop
Masahiko Isaka
Srisuda Trakulnaleamsai
Saovaluk Vimuttipong
Morakot Tanticharoen
Yodhathai Thebtaranonth
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2002
Citation: Journal of Natural Products. Vol.65, No.9 (2002), 1346-1348
Abstract: A new cyclohexadepsipeptide, named hirsutellide A (1), was isolated from a cell extract of the entomopathogenic fungus Hirsutella kobayasii BCC 1660. The structure of 1 was elucidated by analyses of spectroscopic data, and its absolute stereochemistry was addressed by the use of Marfey's method. Hirsutellide A (1) exhibited antimycobacterial and antimalarial activities, but was inactive toward the Vero cell line (at 50 μg/mL).
ISSN: 01633864
Appears in Collections:Scopus 2001-2005

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