Please use this identifier to cite or link to this item:
|Title:||Rectal administration of propylthiouracil in hyperthyroid patients: Comparison of suspension enema and suppository form|
Thailand Ministry of Public Health
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Thyroid. Vol.12, No.7 (2002), 627-631|
|Abstract:||Previous studies have described the therapeutic effects of propylthiouracil (PTU) and methimazole in normal subjects after rectal suppositories. The goal of our study was to compare the pharmacokinetic and pharmacologic effects of a suppository and suspension form of PTU given per rectum. Fifteen newly diagnosed hyperthyroid patients of both genders (ages 21 to 55 years) were randomly given the drug as follows: group 1 (n = 7), a single enema (400 mg of PTU in 90 mL of sterile water) and group 2 (n = 8), two suppositories of polyethylene glycol base (200 mg of PTU in each). The pharmacokinetic study revealed earlier time to peak levels (Tmax) and significantly greater maximal peak levels (Cmax) in group 1 than in group 2, (85.71 ± 12.12 minutes vs. 172.5 ± 26.24 minutes for Tmaxand 3.89 ± 0.34 vs. 2.01 ± 0.38 μg/mL, p < 0.05 for Cmax, respectively). However, the area under the curve (635.16 ± 105.71 vs. 377.87 ± 68.09 μg × min/mL) was not statistically different between both groups. Both forms induced a significant decrease in serum free triiodothyronine (FT3) levels and an increase in serum rT3levels shortly after administration. Four subjects reported a bitter taste 5-10 minutes after receiving the drug. PTU can be effectively absorbed via the rectal route. The enema form appeared to provide better bioavailability than the suppository form. However, both preparations exhibited comparable therapeutic effect.|
|Appears in Collections:||Scopus 2001-2005|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.