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dc.contributor.authorChotiros Daosukhoen_US
dc.contributor.authorKelley Kininghamen_US
dc.contributor.authorEdward J. Kasarskisen_US
dc.contributor.authorWanida Ittaraten_US
dc.contributor.authorDaret K. St. Clairen_US
dc.contributor.otherUniversity of Kentucky College of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-24T02:57:48Z-
dc.date.available2018-07-24T02:57:48Z-
dc.date.issued2002-01-01en_US
dc.identifier.citationOncogene. Vol.21, No.22 (2002), 3603-3610en_US
dc.identifier.issn09509232en_US
dc.identifier.other2-s2.0-0037118584en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037118584&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/20102-
dc.description.abstractManganese superoxide dismutase (MnSOD) has been shown to suppress the development of cancer. Tamoxifen (TAM), a nonsteroidal anti-estrogen that is widely used in chemotherapy, is known to be a modulator of antioxidant status. However, the mechanism by which TAM mediates antioxidant enzyme induction remains unclear. In this study we investigated TAM enhancement of MnSOD induction by TNF-α. The results show that co-treatment with TAM and TNF-α increases the MnSOD promoter/enhancer driven luciferase activity, MnSOD mRNA and protein levels. Interestingly, co-treatment with TAM and TNF-α drastically decreases the binding activity of the p50/p50 homodimer and increases that of the p50/p65 heterodimer compared to TNF-α alone. This change in DNA binding could not be attributed to a decrease in the level of p50, its precursor, p105, or its inhibitors. Furthermore, TAM did not enhance degradation of IκB-α. These results suggest that p50/p50 homodimer may act as an inhibitory complex of MnSOD expression. Modulation of the DNA binding activity in favor of the p50/p65 complex may enhance NF-κB mediated induction of MnSOD by TAM. These findings reveal a potential novel mechanism for the induction of the human MnSOD gene.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037118584&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleTamoxifen enhancement of TNF-α induced MnSOD expression: Modulation of NF-κB dimerizationen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/sj.onc.1205448en_US
Appears in Collections:Scopus 2001-2005

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