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Title: Directed deprotonation-transmetallation of 4-bromopyridine: Flexible routes to substituted pyridines
Authors: Gunter Karig
Nopporn Thasana
Timothy Gallagher
University of Bristol
Chulabhorn Research Institute
Mahidol University
Keywords: Chemistry
Issue Date: 20-May-2002
Citation: Synlett. No.5 (2002), 808-810
Abstract: Halide-directed deprotonation and Li-Zn exchange of 4-bromopyridine 4 provides organozinc 6, which undergoes Pd-mediated coupling to give the 3-aryl-4-bromopyridines 7. Further substitution is achieved to provide the 3,4-disubstituted pyridines 8 and 9, and the 3,4,5-trisubstituted variants 10.
ISSN: 09365214
Appears in Collections:Scopus 2001-2005

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