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|Title:||Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus|
Thailand National Center for Genetic Engineering and Biotechnology
|Citation:||Journal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566|
|Abstract:||Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.|
|Appears in Collections:||Scopus 2001-2005|
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