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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20136
Title: Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus
Authors: Masahiko Isaka
Chotika Suyarnsestakorn
Morakot Tanticharoen
Palangpon Kongsaeree
Yodhathai Thebtaranonth
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Chemistry
Issue Date: 8-Mar-2002
Citation: Journal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566
Abstract: Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037040681&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20136
ISSN: 00223263
Appears in Collections:Scopus 2001-2005

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