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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20179
Title: Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
Authors: Kazuya Omi
Jun Ohashi
Jintana Patarapotikul
Hathairad Hananantachai
Izumi Naka
Sornchai Looareesuwan
Katsushi Tokunaga
University of Tokyo
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2002
Citation: Parasitology International. Vol.51, No.4 (2002), 361-366
Abstract: Human FcγRIIA and FcγRIIIB exhibit genetic polymorphisms, FcγRIIA-131H/R and FcγRIIIB-NA1/NA2, coding for different capacities for IgG binding and phagocytosis. Recently, FcγRIIA-131R was reported to be associated with protection against high-density Plasmodium falciparum infection in Kenya. Furthermore, FcγRIIIB-NA1/NA2 polymorphism was shown to influence FcγRIIA function in an allele-specific manner. In this study, we examined a possible association of FcγRIIA-131H/R and FcγRIIIB-NA1/NA2 polymorphisms with malaria severity in 107 cerebral malaria patients, 157 non-cerebral severe malaria patients, and 202 mild malaria controls living in northwest Thailand. This study reveals that, with the FcγRIIIB-NA2 allele, the FcγRIIA-131H/H genotype is associated with susceptibility to cerebral malaria (OR 1.85, 95% CI 1.14-3.01; P=0.012), although these polymorphisms are not individually involved in the disease severity. Our results suggest that FcγRIIA-131H/R and FcγRIIIB-NA1/NA2 polymorphisms have an interactive effect on host defense against malaria infection. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036882321&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20179
ISSN: 13835769
Appears in Collections:Scopus 2001-2005

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