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Title: Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: A rare simultaneous occurrence
Authors: Sanya Sukpanichnant
Apichati Sivayathorn
Sukon Visudhiphan
Weerapan Ngowthammatas
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2002
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.20, No.2 (2002), 127-133
Abstract: A rare simultaneous occurrence of multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma was diagnosed in a 70-year-old man who presented with fever, polyarthralgia, weight loss, vascular purpura, anemia, generalized lymphadenopathy, and hepatosplenomegaly. He had no risk of HIV infection and serological tests for HIV were negative twice, but a low number of T-cells and a reversed CD4/CD8 ratio were observed. During hospitalization, he developed Kaposi's sarcoma at the right sole. Lymph node biopsies revealed multicentric Castleman's disease together with a large B-cell lymphoma, which showed monotypic IgM-lambda lymphocytes. To our knowledge, this is the first report in which systemic manifestations of all three diseases occurred simultaneously prior to any specific treatment. The altered immune status and human herpesvirus-8 infection might have played a role in the pathogenesis of this occurrence.
ISSN: 0125877X
Appears in Collections:Scopus 2001-2005

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