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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20230
Title: Intestinal helminths and malnutrition are independently associated with protection from cerebral malaria in Thailand
Authors: M. Nacher
P. Singhasivanon
S. Treeprasertsuk
S. Vannaphan
B. Traore
S. Looareesuwan
F. Gay
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2002
Citation: Annals of Tropical Medicine and Parasitology. Vol.96, No.1 (2002), 5-13
Abstract: Although human infection with Ascaris appears to be associated with protection from cerebral malaria, there are many potential socio-economic and nutritional confounders related to helminth infection that need to be considered. In a hospital-based study, 37 cases of cerebral malaria and 61 cases of non-severe malaria with high parasite biomass (i.e. hyperparasitaemia and/or circulating schizonts) answered a structured questionnaire and were screened for intestinal helminths. Logistic regression was then used to adjust for the potential confounders. The adjusted odds ratios (OR) and their 95% confidence intervals (CT) still showed a significant protective association for helminths (OR = 0.24; CI = 0.07-0.78; P= 0.02) and malnutrition (OR = 0.11; CI = 0.02-0.58; P= 0.01), with no evidence of interaction between the two. There was also a significant dose-effect trend for the helminth infections (P= 0.048). These results, despite coming from a hospital-based study, indicate that the apparent association between helminths and protection from cerebral malaria is not the result of socio-economic or nutritional confounders.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036105109&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20230
ISSN: 00034983
Appears in Collections:Scopus 2001-2005

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