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Title: Haemozoin as a marker of placental parasitization
Authors: Rose McGready
Alan Brockman
Thein Cho
Martin A. Levesque
Ariana N. Tkachuk
Steven R. Meshnick
François Nosten
Shoklo Malaria Research Unit
Mahidol University
John Radcliffe Hospital
University of Michigan School of Public Health
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2002
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.96, No.6 (2002), 644-646
Abstract: Both Plasmodium vivax and P. falciparum malaria can cause the delivery of low birthweight babies. In this report, we have quantitated haemozoin levels in placentas from women living on the Thai-Burmese border in a region of low transmission for both P. falciparum and P. vivax malaria from June 1995 to January 2000. P. falciparum malaria infections during pregnancy lead to the accumulation of haemozoin (malaria pigment) in the placenta, especially in infections near term and in primigravid pregnancies. Haemozoin concentration was not associated with adverse birth outcomes. Women with P. vivax infections during pregnancy do not have measurable levels of placental haemozoin suggesting that P. vivax-infected erythrocytes do not accumulate in the placenta as much as P. falciparum-infected ones.
ISSN: 00359203
Appears in Collections:Scopus 2001-2005

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