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dc.contributor.authorWatip Boonyasrisawaten_US
dc.contributor.authorPinya Pulsawaten_US
dc.contributor.authorPa Thai Yenchitsomanusen_US
dc.contributor.authorSathit Vannasaengen_US
dc.contributor.authorPakorn Pramukkulen_US
dc.contributor.authorChaicharn Deerochanawongen_US
dc.contributor.authorSutin Sriussadapornen_US
dc.contributor.authorSirirat Ploybutren_US
dc.contributor.authorThawatchai Pasurakulen_US
dc.contributor.authorNapatawn Banchuinen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRajavithi Hospitalen_US
dc.contributor.otherPhya Thai 2 Hospitalen_US
dc.contributor.otherSappasitthiprasong Hospitalen_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.33, No.2 (2002), 365-372en_US
dc.description.abstractFibrocalculous pancreatopathy is a form of diabetes, associated with tropical chronic calcific pancreatitis, in which islet β-cell loss and pancreatic stone formation are found. It is likely to be a multifactorial disease with both genetic and environmental components. Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopathy. In this study, reg1α, and reg1β mRNAs were isolated from peripheral blood lymphocytes obtained from 16 patients with fibrocalculous pancreatopathy, 42 patients with type 1 diabetes, 37 patients with type 2 diabetes, and 22 normal controls. mRNAs were amplified by reverse-transcription polymerase chain reaction (RT-PCR) and analysed by a single strand conformation polymorphism (SSCP) technique. The reg1α and reg1β mRNAs were isolated, indicating the ectopic expression of these genes in peripheral blood lymphocytes; however, variation among mobility patterns was not observed in the SSCP analysis of the RT-PCR products. The results indicated that there was no abnormality of the reg1α and reg1β mRNAs obtained from the study groups.en_US
dc.rightsMahidol Universityen_US
dc.titleAnalysis of the REG1α and REG1β gene transcripts in patients with fibrocalculous pancreatopathyen_US
Appears in Collections:Scopus 2001-2005

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