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Title: Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
Authors: Sujittra Chaisavaneeyakorn
Julie M. Moore
Caroline Othoro
Juliana Otieno
Sansanee C. Chaiyaroj
Ya Ping Shi
Bernard L. Nahlen
Altaf A. Lal
Venkatachalam Udhayakumar
National Center for Infectious Diseases
The University of Georgia
Mahidol University
Kenya Medical Research Institut
New Nyanza Provincial General Hospital
Organisation Mondiale de la Sante
Keywords: Medicine
Issue Date: 1-Nov-2002
Citation: Journal of Infectious Diseases. Vol.186, No.9 (2002), 1371-1375
Abstract: Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids. The present study investigated whether plasma MIF levels are altered in pregnant women with placental malaria (PM) and/or human immunodeficiency virus (HIV) infection. For the first time it is demonstrated that MIF levels in the intervillous blood (IVB) plasma were significantly elevated, compared with that in both peripheral plasma (500-fold) and cord plasma (4.6-fold; P < .01). IVB mononuclear cells also produced significantly higher levels of MIF, compared with that of peripheral blood mononuclear cells. PM was associated with increased levels of MIF in the IVB plasma (P < .02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P < .05). HIV infection did not significantly alter MIF levels in any site examined.
ISSN: 00221899
Appears in Collections:Scopus 2001-2005

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