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Title: A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis
Authors: Paul N. Newton
Hung Thai Le
Quoc Tip Nguyen
Jennifer M. Short
Wirongrong Chierakul
Adul Rajanuwong
Punnee Pitisuttithum
Sanchai Chasombat
Benjaluck Phonrat
Wirach Maek-A-Nantawat
Reungsilp Teaunadi
David G. Lalloo
Nicholas J. White
Mahidol University
Sappasitthiprasong Hospital
North East Regional Infectious Disease Hospital
John Radcliffe Hospital
Liverpool School of Tropical Medicine
Institute of Malariology, Parasitology and Entomology
Keywords: Medicine
Issue Date: 15-Sep-2002
Citation: Clinical Infectious Diseases. Vol.35, No.6 (2002), 769-772
Abstract: We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of ≥200 mm H2O. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
ISSN: 10584838
Appears in Collections:Scopus 2001-2005

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