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Title: The efficacy and tolerability of an angiotensin II receptor blocker, Telmisartan, in Thai patients with mild to moderate essential hypertension
Authors: Peera Buranakitjaroen
Surachai Saravich
Meta Phoojaroenchanachai
Pantip Sangprasert
Mahidol University
Keywords: Medicine
Issue Date: 1-Sep-2002
Citation: Journal of the Medical Association of Thailand. Vol.85, No.9 (2002), 968-977
Abstract: This open-labeled single-blinded study was performed to evaluate the efficacy and tolerability of telmisartan in the treatment of mild to moderate essential hypertension. Each patient was assigned to take a placebo for 4 weeks followed by once daily-titrated telmisartan (40-80 mg) for 8 weeks. "Office BP" and "24-hour ambulatory BP" measurements (24-h ABPM) were recorded as scheduled. Thirty-one patients (10 males: 21 females) with a mean age of 48.1 years were enrolled. The final SBP/DBP reductions of 14.6 ± 14.2/9.9 ± 6.2 mm Hg were obtained. Full response defined as office DBP reduction of ≥10 mm Hg from baseline and/or DBP <90 mm Hg was achieved in 73.3 per cent of cases. Excluding 5 cases of white coat HT diagnosed by 24-h ABPM, full response rate (DBP reduction of ≥10 mm Hg from baseline and/or <85 mm Hg) was 76 per cent. Trough to peak ratio and smoothness index for SBP/DBP were highly acceptable (0.75/0.76 and 0.97/1.01, respectively). There were 4 cases of adverse events (2 cases of dizziness, 1 case of headache, and 1 case of acute myocardial infarction).
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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