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Title: A double-blind, randomized study comparing postoperative pain management using epidural ropivacaine with intravenous ketorolac or intravenous ketorolac alone following transabdominal hysterectomy
Authors: Thitima Chinachoti
Supranee Niruthisard
Orathai Tuntisirin
Somboon Thienthong
Prasong Khunsongkiet
Fidel Payawal
Iluminada Camagay
Ricardo De Castro
Mahidol University
Chulalongkorn University
Khon Kaen University
Chiang Mai University
Keywords: Medicine
Issue Date: 1-Sep-2002
Citation: Journal of the Medical Association of Thailand. Vol.85, No.SUPPL. 3 (2002)
Abstract: Objective: The aim of this study is to compare the effect on postoperative pain of epidural ropivacaine in combination with intravenous ketorolac with intravenous ketorolac alone following transabdominal hysterectomy. Design: A multi-center, randomized, double-blind study was conducted in Thailand and the Philippines to assess postoperative pain management in 107 patients given ketorolac alone or in combination with epidural ropivacaine following transabdominal hysterectomy. Pain score was assessed using a 100-mm visual analogue pain scale (VAS). Results: The VAS scores for pain on coughing and at rest were significantly better in the ropivacaine group. The number of patients who asked for morphine in addition was higher in the ketorolac group compared to the ropivacaine + ketorolac group. The time taken to carry out the first three ambulatory steps was similar for both the two treatment groups. A higher degree of motor block was observed in the ropivacaine group over time. The adverse events observed were similar in both groups. Conclusion: We demonstrated that epidural infusion of ropivacaine in addition with intravenous ketorolac gave superior pain relief at rest and on coughing in patients undergoing transabdominal hysterectomy when compared to the group receiving intravenous ketorolac alone.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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