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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20408
Title: Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand
Authors: Jun Ohashi
Izumi Naka
Jintana Patarapotikul
Hathairad Hananantachai
Sornchai Looareesuwan
Katsushi Tokunaga
University of Tokyo
Mahidol University
Keywords: Medicine
Issue Date: 15-Aug-2002
Citation: Journal of Infectious Diseases. Vol.186, No.4 (2002), 578-581
Abstract: A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ≥15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P = .0029, X2test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P = .0041). The single nucleotide substitution, -954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at -5.2, -5.5, -5.8, and -6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037103603&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20408
ISSN: 00221899
Appears in Collections:Scopus 2001-2005

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