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Title: Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria
Authors: Paul N. Newton
Michele Van Vugt
Paktiya Teja-Isavadharm
Duangsuda Siriyanonda
Maneerat Rasameesoroj
Pramote Teerapong
Ronatrai Ruangveerayuth
Thra Slight
Francois Nosten
Yupin Suputtamongkol
Sornchai Looareesuwan
Nicholas J. White
Mahidol University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 9-Apr-2002
Citation: Antimicrobial Agents and Chemotherapy. Vol.46, No.4 (2002), 1125-1127
Abstract: Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated faiciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.
ISSN: 00664804
Appears in Collections:Scopus 2001-2005

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